%PDF-1.4
%
42 0 obj
<>
endobj
40 0 obj
<>stream
Acrobat Distiller 5.0.5 (Windows)
2007-09-04T07:31:48Z
2015-02-18T05:55:23-08:00
2015-02-18T05:55:23-08:00
application/pdf
fdz
UTXP_02_245877.tex
uuid:64adf950-1dd2-11b2-0a00-4b08271dd700
uuid:64adf956-1dd2-11b2-0a00-0ef600000000
endstream
endobj
37 0 obj
<>
endobj
38 0 obj
<>
endobj
43 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
1 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>>
endobj
5 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>>
endobj
9 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
12 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
16 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
19 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>>
endobj
23 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
113 0 obj
[116 0 R]
endobj
114 0 obj
<>stream
BT
/GS0 gs
/T1_0 1 Tf
9.9626 0 0 9.9626 37.9427 749.13 Tm
(664)Tj
22.1425 0 Td
[(DUNNICK)-249.9 (ET)-250 (AL.)]TJ
10.4608 0 0 10.4608 445.623 749.13 Tm
(T)Tj
-0.00011 Tc 8.3686 0 0 8.3686 451.178 749.13 Tm
(OXICOLOGIC)Tj
0 Tc 10.4608 0 0 10.4608 505.854 749.13 Tm
(P)Tj
-0.00011 Tc 8.3686 0 0 8.3686 511.514 749.13 Tm
(ATHOLOGY)Tj
0 Tc 7.9701 0 0 7.9701 37.9427 725.28 Tm
[(Naik,)-204.9 (S.)-204.9 (D.,)-204.8 (and)-204.8 (Freudenber)17.8 (ger)39.9 (,)-204.8 (R.)-204.8 (S.)-204.9 (\(2004\).)-204.9 (Ephedra-associated)-205.2 (cardiomyopa-)]TJ
-0.0025 Tc 2.25 -1.2499 Td
[(thy)62.5 (.)]TJ
/T1_1 1 Tf
0 Tc 1.708 0 Td
[(Ann)-250.1 (Pharmacother)]TJ
/T1_2 1 Tf
7.888 0 Td
(38)Tj
/T1_0 1 Tf
[(\(3\),)-250.1 (400\2053.)]TJ
-11.8459 -1.2501 Td
[(National)-207.1 (T)80 (oxicology)-207.1 (Program)-207 (\(2004\).)-207.1 (Ephedrine,)-207.1 (Ma)-206.9 (Huang,)-207 (and)-206.9 (caf)25 (feine)-207 (com-)]TJ
2.25 -1.25 Td
[(bination;)-250.2 (special)-250.1 (chemical)-250.2 (analysis)-250.2 (report.)]TJ
/T1_1 1 Tf
17.053 0 Td
[(December)-250.2 (17,)-250.1 (2004)]TJ
/T1_0 1 Tf
[0.3 (.)]TJ
-19.303 -1.2499 Td
[(National)-202.4 (T)80 (oxicology)-202.6 (Program)-202.4 (\(2006\).)-202.5 (Ephedrine)]TJ
/T1_3 1 Tf
19.4565 0 Td
(+)Tj
/T1_0 1 Tf
0.9822 0 Td
[(Ma)-202.4 (Huang)]TJ
/T1_3 1 Tf
4.4036 0 Td
(+)Tj
/T1_0 1 Tf
0.9824 0 Td
[(Caf)24.9 (feine)-202.3 (com-)]TJ
-23.5747 -1.2501 Td
[(bination)-272.5 (in)-272.4 (Male)-272.6 (Fischer)-272.5 (344)-272.4 (rat)-272.4 (plasma:)-272.5 (biological)-272.7 (sample)-272.5 (analysis.)]TJ
/T1_1 1 Tf
27.75 0 Td
(RTI)Tj
-27.75 -1.25 Td
[(under)-250.1 (NIH)-250.1 (Contr)14.9 (act)-250.1 (No)-250 (N01-ES-65554.)]TJ
/T1_0 1 Tf
16.2069 0 Td
[(Chem)-250.1 (T)80 (ask)-250 (No.)-250.1 (CHEM08401.)]TJ
-18.457 -1.2499 Td
[(Ne)25 (w)-250 (Y)110 (ork)-250 (T)35 (imes)-250.1 (\(2005\).)-250.1 (T)35 (ime)-250.1 (to)-250 (ban)-250.1 (ephedra.)]TJ
/T1_1 1 Tf
18.902 0 Td
[(April)-250.1 (21,)-250.1 (2005)]TJ
/T1_0 1 Tf
[0.2 (.)]TJ
-18.902 -1.2501 Td
[(Nyska,)-350 (A.,)-349.9 (Murphy)65 (,)-349.7 (E.,)-349.9 (F)15 (ole)15 (y)65 (,)-349.9 (J.)-349.9 (F)80 (.,)-349.8 (Collins,)-350 (B.)-349.9 (J.,)-349.9 (Petranka,)-349.9 (J.,)-349.9 (Ho)25 (wden,)-350 (R.,)]TJ
2.25 -1.25 Td
[(Hanlon,)-389.7 (P)111 (.,)-389.4 (and)-389.6 (Dunnick,)-389.6 (J.)-389.5 (K.)-389.4 (\(2005\).)-389.6 (Acute)-389.6 (hemorrhagic)-389.6 (myocardial)]TJ
0 -1.2499 TD
[(necrosis)-272.3 (and)-272.2 (sudden)-272.1 (death)-272.2 (of)-272.2 (rats)-272.1 (e)15 (xposed)-272.3 (to)-272.1 (a)-272.1 (combination)-272.3 (of)-272.2 (ephedrine)]TJ
0 -1.2501 TD
[(and)-250.1 (caf)24.9 (feine.)]TJ
/T1_1 1 Tf
5.389 0 Td
[(T)92 (oxicol)-250.1 (Sci)]TJ
/T1_2 1 Tf
4.6301 0 Td
(83)Tj
/T1_0 1 Tf
[(\(2\),)-250.1 (388\20596.)]TJ
-12.269 -1.2499 Td
[(Persk)14.9 (y)65 (,)-148.4 (A.)-148.4 (M.,)-148.4 (Berry)64.9 (,)-148.4 (N.)-148.3 (S.,)-148.4 (Pollack,)-148.5 (G.)-148.4 (M.,)-148.4 (and)-148.4 (Brouwer)39.8 (,)-148.4 (K.)-148.3 (L.)-148.4 (\(2004\).)-148.5 (Modelling)]TJ
2.25 -1.2501 Td
[(the)-254.4 (cardio)14.9 (v)25 (ascular)-254.5 (ef)25 (fects)-254.6 (of)-254.4 (ephedrine.)]TJ
/T1_1 1 Tf
15.951 0 Td
[(Br)-254.4 (J)-254.4 (Clin)-254.6 (Pharmacol)]TJ
/T1_2 1 Tf
8.6286 0 Td
(57)Tj
/T1_0 1 Tf
[(\(5\),)-254.4 (552\205)]TJ
-24.5796 -1.25 Td
(62.)Tj
-2.25 -1.2499 Td
[(Peters,)-328.3 (C.)-328 (M.,)-328.2 (O\220Neill,)-328.3 (J.)-328 (O.,)-328.2 (Y)110 (oung,)-328.1 (J.)-328.1 (B.,)-328.2 (and)-328.1 (Bott-Silv)14.8 (erman,)-328.3 (C.)-328 (\(2005\).)-328.3 (Is)]TJ
2.25 -1.25 Td
[(there)-340.3 (an)-340.3 (association)-340.6 (between)-340.4 (ephedra)-340.4 (and)-340.3 (heart)-340.3 (f)10 (ailure?)-340.5 (a)-340.2 (case)-340.3 (series.)]TJ
/T1_1 1 Tf
28.806 0 Td
(J)Tj
-28.806 -1.2501 Td
[(Car)36.9 (d)-250 (F)75 (ail)]TJ
/T1_2 1 Tf
4.111 0 Td
(11)Tj
/T1_0 1 Tf
[(\(1\),)-250.1 (9\20511.)]TJ
-6.361 -1.2499 Td
[(Ruben,)-362.4 (Z.,)-362.4 (Arceo,)-362.4 (R.)-362.3 (J.,)-362.4 (Bishop,)-362.4 (S.)-362.3 (P)111 (.,)-362.3 (El)10 (well,)-362.5 (M.)-362.3 (R.,)-362.3 (K)25 (erns,)-362.5 (W)92.1 (.)-362.4 (D.,)-362.3 (Mes\223n,)]TJ
2.25 -1.2501 Td
[(G.)-413.3 (M.,)-413.3 (Sandusk)14.8 (y)-413.4 (G.)-413.3 (E.,)-413.3 (and)-413.3 (V)111 (an)-413.3 (Vleet)-413.5 (J.)-413.3 (F)80 (.)-413.3 (\(2000\).)]TJ
/T1_1 1 Tf
22.31 0 Td
[(Non-pr)44.9 (olifer)14.9 (ative)]TJ
-22.31 -1.2501 Td
[(lesions)-236.8 (of)-236.8 (the)-236.7 (heart)-236.7 (and)-236.8 (vasculatur)36.8 (e)-236.6 (in)-236.6 (r)15 (ats)]TJ
/T1_0 1 Tf
16.9936 0 Td
[(.)-236.7 (STP/ARP/AFIP)110.7 (,)-236.6 (W)80 (ashington,)]TJ
-16.9936 -1.2499 Td
(DC.)Tj
-2.25 -1.25 Td
[(Shack)9.9 (elford,)-211.9 (C.,)-211.8 (Long,)-211.9 (G.,)-211.8 (W)80 (olf,)-211.8 (J.,)-211.8 (Ok)10 (erber)17.9 (g,)-211.8 (C.,)-211.8 (and)-211.8 (Herbert,)-211.9 (R.)-211.8 (\(2002\).)-211.9 (Qual-)]TJ
2.25 -1.25 Td
[(itati)24.9 (v)15 (e)-367.8 (and)-367.8 (quantitati)24.8 (v)15 (e)-367.7 (analysis)-367.9 (of)-367.8 (nonneoplastic)-368 (lesions)-367.9 (in)-367.8 (toxiciology)]TJ
0 -1.2499 TD
(studies.)Tj
/T1_1 1 Tf
3.278 0 Td
[(T)92 (oxicol)-250.1 (P)80 (athol)]TJ
/T1_2 1 Tf
5.995 0 Td
(30)Tj
/T1_0 1 Tf
[(,)-250 (93\2056.)]TJ
22.227 30 Td
[(U.)-371.3 (S.)-371.2 (F)15 (ood)-371.3 (and)-371.2 (Drug)-371.3 (Administration)-371.6 (\(1995\).)-371.3 (Dietary)-371.4 (supplement)-371.5 (health)-371.2 (and)]TJ
2.25 -1.25 Td
[(education)-250.2 (act)-250.1 (of)-250 (1994.)-500.1 (http://wwwcfsanfdago)14.5 (v/)]TJ
/T1_3 1 Tf
19.093 0 Td
(\002)Tj
/T1_0 1 Tf
(dms/dietsupphtml.)Tj
-21.3431 -1.2501 Td
[(U.)-307.3 (S.)-307.2 (F)15 (ood)-307.2 (and)-307.3 (Drug)-307.2 (Administration)-307.6 (\(2004\).)-307.3 (Final)-307.3 (rule)-307.2 (declaring)-307.4 (dietary)-307.3 (sup-)]TJ
2.25 -1.2499 Td
[(plements)-237.3 (containing)-237.3 (ephedrine)-237.4 (alkaloids)-237.3 (adulterated)-237.4 (because)-237.3 (the)15 (y)-237.1 (present)]TJ
0 -1.2501 TD
[(unreasonable)-250.3 (risk;)-250.1 (\223nal)-250 (rule.)]TJ
/T1_1 1 Tf
-0.075 Tc 11.637 0 Td
[(Fe)-75 (d)-325 (R)-75 (e)-35 (g)]TJ
/T1_2 1 Tf
0 Tc 3.4949 0 Td
(69)Tj
/T1_0 1 Tf
[(,)-250 (6788\205854.)]TJ
-17.382 -1.25 Td
[(U.S.)-336.1 (Federal)-336.2 (District)-336.2 (Court)-336.1 (U.)-336 (\(2005\).)-336.1 (http://wwwutduscourtsgo)14.5 (v/documents/)]TJ
2.25 -1.2499 Td
(profpagehtml.)Tj
-2.25 -1.25 Td
[(V)111 (anak)9.9 (oski,)-264.6 (J.,)-264.4 (Stromber)17.8 (g,)-264.5 (C.,)-264.5 (and)-264.5 (Seppala,)-264.6 (T)74 (.)-264.5 (\(1993\).)-264.6 (Ef)25 (fects)-264.5 (of)-264.5 (a)-264.5 (sauna)-264.5 (on)-264.5 (the)]TJ
2.25 -1.2501 Td
[(pharmacokinetics)-219.5 (and)-219.2 (pharmacodynamics)-219.7 (of)-219.2 (midazolam)-219.3 (and)-219.2 (ephedrine)-219.3 (in)]TJ
0 -1.2499 TD
[(health)-250.1 (young)-250.1 (w)10 (omen.)]TJ
/T1_1 1 Tf
8.8779 0 Td
[(Eur)-250.1 (J)-250 (Clin)-250.1 (Pharmacol)]TJ
/T1_2 1 Tf
9.1111 0 Td
(45)Tj
/T1_0 1 Tf
[(,)-250 (377\20581.)]TJ
-20.239 -1.25 Td
[(V)111 (ansal,)-321.9 (S.)-321.7 (S.,)-321.8 (and)-321.7 (Feller)39.9 (,)-321.8 (D.)-321.7 (R.)-321.8 (\(1999\).)-321.8 (Direct)-321.9 (ef)25 (fecs)-321.7 (of)-321.8 (ephedrine)-321.8 (isomers)-321.9 (on)]TJ
2.25 -1.2499 Td
[(human)-250.1 (B-adrener)17.8 (gic)-250 (receptor)-250.2 (subtypes.)]TJ
/T1_1 1 Tf
15.95 0 Td
[(Bioc)14.9 (hem)-250 (Pharmacol)]TJ
/T1_2 1 Tf
8.428 0 Td
(58)Tj
/T1_0 1 Tf
[(,)-250 (807\20510.)]TJ
-26.628 -1.25 Td
[(V)75 (uk)10 (o)15 (vich,)-223.7 (M.)-223.6 (D.,)-223.7 (Schoorman,)-223.9 (R.,)-223.6 (Heilman,)-223.8 (C.,)-223.7 (Jacob,)-223.6 (P)111 (.,)-223.6 (3rd,)-223.7 (and)-223.5 (Beno)24.9 (witz,)-223.7 (N.)]TJ
2.25 -1.25 Td
[(L.)-281.2 (\(2005\).)-281.3 (Caf)24.9 (feine-herbal)-281.4 (ephedra)-281.4 (combination)-281.4 (increases)-281.3 (resting)-281.3 (ener)17.9 (gy)]TJ
T*
[(e)15 (xpenditure,)-308 (heart)-308 (rate)-307.8 (and)-307.8 (blood)-307.8 (pressure.)]TJ
/T1_1 1 Tf
17.6046 0 Td
[(Clin)-307.9 (Exp)-307.8 (Pharmacol)-308 (Physiol)]TJ
/T1_2 1 Tf
-17.6046 -1.25 Td
(32)Tj
/T1_0 1 Tf
[(\(1\2052\),)-250.1 (47\20553.)]TJ
-2.25 -1.25 Td
[(W)80 (ellman,)-257.4 (P)111 (.)-257.2 (J.,)-257.3 (Miller)39.9 (,)-257.3 (D.)-257.3 (K.,)-257.3 (and)-257.3 (Ho,)-257.3 (D.)-257.3 (H.)-257.3 (\(2003\).)-257.4 (Noradrener)17.8 (gic)-257.3 (modulation)]TJ
2.25 -1.2499 Td
[(of)-250 (ephedrine-induced)-250.4 (hypophagia.)]TJ
/T1_1 1 Tf
13.936 0 Td
(Synapse)Tj
/T1_2 1 Tf
3.5269 0 Td
(48)Tj
/T1_0 1 Tf
[(,)-250 (18\20524.)]TJ
-19.7129 -1.25 Td
[(White,)-396.8 (L.)-396.8 (M.,)-396.7 (Gardner)39.8 (,)-396.6 (S.)-396.8 (F)80 (.,)-396.6 (Gurle)14.9 (y)65 (,)-396.6 (B.)-396.8 (J.,)-396.7 (Marx,)-396.7 (M.)-396.8 (A.,)-396.7 (W)80 (ang,)-396.7 (P)111 (.)-396.7 (L.,)-396.7 (and)]TJ
2.25 -1.2501 Td
[(Estes,)-453.6 (E.)-453.5 (\(1997\).)-453.7 (Pharmacokinetics)-453.9 (and)-453.6 (cardio)14.9 (v)25 (ascular)-453.6 (ef)25 (fects)-453.6 (of)-453.5 (Ma-)]TJ
T*
[(Huang)-396.9 (\(Ephedra)-397.1 (sinica\))-396.9 (in)-396.8 (normotensi)24.8 (v)15 (e)-396.9 (adults.)]TJ
/T1_1 1 Tf
20.1988 0 Td
[(J)-396.6 (Clin)-396.9 (Pharmacol)]TJ
/T1_2 1 Tf
7.8013 0 Td
(37)Tj
/T1_0 1 Tf
(,)Tj
-27.9999 -1.25 Td
(116\20522.)Tj
-2.25 -1.25 Td
[(W)40 (ilkinson,)-274.1 (G.)-273.8 (R.,)-273.9 (and)-273.8 (Beck)9.9 (ett,)-273.9 (A.)-273.8 (H.)-273.9 (\(1968\).)-273.9 (Absorption,)-274.1 (metabolism,)-274.1 (and)-273.8 (e)15 (x-)]TJ
2.25 -1.2499 Td
[(cretion)-297.6 (of)-297.5 (the)-297.5 (ephedrines)-297.7 (in)-297.5 (man)-297.6 (II.)]TJ
/T1_1 1 Tf
14.6624 0 Td
[(J)25 (ournal)-297.6 (of)-297.5 (Pharmaceutical)-297.8 (Sciences)]TJ
/T1_2 1 Tf
-14.6624 -1.2501 Td
(57)Tj
/T1_0 1 Tf
[(,)-250 (1933\2058.)]TJ
ET
BT
/GS1 gs
/T1_4 1 Tf
5 0 0 5 296.6925 27 Tm
( at Tel Aviv University on February 18, 2015)Tj
0 0 1 rg
/GS1 gs
-7.61499 0 Td
(tpx.sagepub.com)Tj
0 g
/GS1 gs
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
47 0 obj
<>
endobj
56 0 obj
<>
endobj
60 0 obj
<>
endobj
64 0 obj
<>
endobj
94 0 obj
<>
endobj
50 0 obj
<>
endobj
48 0 obj
<>
endobj
58 0 obj
<>stream
HTn >
ibLZMmwђT$߾k- fgX65؛Uce^Bq4
ڨGTtHmKewJ.opxJ"p->>[ m
4_; QC).vI^y>UVe7E?/[%碮ED{